March 5, 2021 /

Assessing the Risk of Arrhythmias and Sudden Cardiac Events in Duchenne (March 4, 2021)

Cardiac involvement in Duchenne starts in early childhood, and by the end of the second decade, weakening of the heart muscle is observed in over 40% of men and can lead to heart failure, heart rhythm abnormalities and sudden cardiac death. On March 4, 2021, our presenters discussed a multicenter trial to better assess the risk of arrhythmias in patients with Duchenne. The role of ambulatory EKG monitors (Holter and Event monitors; implantable loop recorders), cardiac imaging (cardiac MRI) and novel computational technologies (computer simulations using patient-specific 3D heart models) for risk stratification of sudden death were discussed. This study is supported by PPMD and the Department of Defense Duchenne Muscular Dystrophy Research Program (DMDRP).

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