Considering a Clinical Trial

If you are considering a clinical trial, we have two resources that may be very helpful for you. The first is a Clinical Trial Decision Guide that you can download and print at home. The second is a list of questions that you can print and take to your first meeting with the clinical trial team.

Clinical Trial Decision Guide

The following Clinical Trial Decision Guides are worksheets that will help you decide whether or not clinical trial participation is right for you and your family. The goal of these worksheets is to help you think through your decision so that you have the most impactful experience possible.

These worksheets use interactive functions that are ONLY supported by the Adobe Acrobat Reader®. Click the links below to download and save a copy of the zip file that contains the Adobe® PDF. You can then open them using your Adobe Acrobat Reader® software.

The PDF must be opened with Adobe® Reader or Adobe® Acrobat to be viewed correctly. If you do not have Adobe Reader® or Adobe® Acrobat® installed on your computer, please install the free Adobe Reader from the trusted manufacturer website: https://get.adobe.com/reader/.

Please note that the Decision Guides are not yet available for use on a smartphone.

Questions to Ask your Clinical Trial Team

In order to help you prepare for meeting with the clinical trial team (study team) it may be helpful to do the following:

  • Plan ahead and write down possible questions to ask, or print this list.
  • Ask a friend or relative to come along for support and to hear the responses to questions.
  • Record the discussion to replay later.
  • You may also want to download and complete the Clinical Trial Decision Guide (above) to help aid the discussion.

You and your family should know as much as possible about the research study or clinical trial and should feel comfortable asking your study team questions. It is important to ask the study team questions about the goals of the trial and the likelihood of any benefits during and after the trial.

Below are some questions to include:

The Study
    • What is the purpose of the study? (see more info on Types and Phases of clinical trials)
    • Why do the researchers think the approach being tested will work?
    • Who is going to be in the study? (learn more about exclusion/inclusion criteria)
    • Has this test/intervention/treatment been tested before?
    • Who is sponsoring the study?
    • Who has reviewed and approved the study?
    • What are the medical credentials and experience of the researchers and other study personnel?
    • How are the study results and safety of the participants being monitored?
    • How will the results of the study be shared? Will the results be provided to me?
    • Is there a placebo arm of the study? If so, will I know if I am receiving a placebo or not? (see “Placebo” video for more info)
Participation and Care 
    • What kinds of tests and experimental treatments are involved? Will hospitalization be required?
    • What is the frequency of tests/treatments?
    • How do the tests in the study compare to the normal care?
    • Will I be able to take my regular medicine while in the study?
    • Where will I receive my medical care and who will be in charge of it? Can I still see my own doctor?
    • Will treatments, tests, or procedures be painful? And if so, can the pain be controlled?
    • How long is the study?
    • Are there follow-up visits after the study is complete?
    • See the video “Trial Logistics” for more information
Personal Issues
    • How might this trial affect my daily life? How will it impact the rest of the family?
    • Is there support for people in the study and their families?
    • Can I talk to with people who are already in the study?
    • See the video “Trial Logistics” for more information
Cost Issues
    • Who will pay for the experimental treatment? If I am responsible for any costs what will the approximate charges be?
    • Will I be reimbursed for expenses such as travel? And if so, how is that done?
    • What is health insurance likely to cover?
    • Who can help answer questions from the insurance company or health plan?
    • See the video “Trial Logistics” for more information
Possible Risks and Benefits
    • What are the possible short-term benefits?
    • What are the possible long-term benefits?
    • What are the short term risks, such as side effects?
    • What are other possible long term risks?
    • What other treatment options are available?
    • How do the possible risks, side effects, and benefits in the study compare with my current treatment?
    • Can I participate in other trials?
    • See the following videos for info on this topic: “Benefits”, “Risks”andManaging Expectations”