DUVYZAT™ (givinostat) is an ‘HDAC inhibitor’ in that it blocks enzymes called histone deacetylases (HDACs), which are involved in turning genes ‘on’ and ‘off’ within cells and can reduce muscle regeneration in Duchenne. By inhibiting HDAC activity DUVYZAT™ may help to activate muscle repair mechanisms to increase muscle fiber regeneration, reduce inflammation, and reduce fibrosis.

Status

DUVYZAT™ (givinostat) is a histone deacetylase (HDAC) inhibitor indicated for individuals diagnosed with Duchenne muscular dystrophy from six years of age and older. For additional resources regarding eligibility and access, view PPMD’s Insurance Access & Coverage Roadmap.

Sponsor

This program was sponsored by Italfarmaco SpA and commercialized in the US by ITF Therapeutics.

Media Library

MARCH 2024

Webinar: Community Update with ITF Therapeutics: Introducing DUVYZAT™ (givinostat)

ITF Therapeutics joined PPMD on March 27, 2024 to provide the community with an opportunity to meet members of the ITF Therapeutics team to learn more about their organization and next steps to support the availability of DUVYZAT.
JUNE 2021

Italfarmaco Presents at the PPMD 2021 Virtual Annual Conference

Pre-recorded content for PPMD's 2021 Virtual Annual Conference On-Demand Library
APRIL 2020

Webinar: Italfarmaco Provides Givinostat Update

Italfarmaco joined PPMD for a webinar on April 22, 2020 to update the community about Italfarmaco’s development of Givinostat and the recent results of the futility analysis of the enrolling Phase 3 confirmatory study in Duchenne muscular dystrophy.
JUNE 2019

Italfarmaco Presents at the PPMD 2019 Annual Conference
MARCH 2019

Webinar: Italfarmaco Provides Givinostat Update

Italfarmaco joined PPMD for a webinar on March 27, 2019 to update the community about Italfarmaco's development of Givinostat and the enrolling Phase 3 confirmatory study in Duchenne muscular dystrophy.
JUNE 2018

Italfarmaco Presents at the PPMD 2018 Annual Conference
JAN 2018

Webinar: Italfarmaco Provides Givinostat Update

Italfarmaco joined PPMD for a webinar on January 24, 2018 to update the Duchenne community about Italfarmaco's development of Givinostat and the enrolling Phase 3 confirmatory study in Duchenne muscular dystrophy.
APRIL 2017

Webinar: Givinostat in Duchenne

Parent Project Muscular Dystrophy and Italfarmaco hosted a webinar on April 26, 2017 to discuss Italfarmaco's investigational drug Givinostat (a histone deacetylase (HDAC) inhibitor) and how it works in Duchenne. Our speakers presented a brief history of the development program, including pre-clinical results and preliminary results of the current Phase 2 clinical trial, study 43, which is ongoing in Italy, and answered questions from our community.