PPMD is closely following any changes or updates to current Covid-19 vaccine recommendations, including new recommendations for immunocompromised individuals. Under guidance of the Centers for Disease Control and Prevention (CDC) to understand how current guidelines apply to people with Duchenne, we are happy to update our Covid-19 Vaccination & Duchenne resource page.
These updates reflect the need for people with Duchenne who are immunocompromised (receiving ≥20mg Prednisone daily, or ≥24mg Deflazacort daily) to receive a third dose of the Pfizer-BioNTech or Moderna vaccines at least 28 days after the second dose. These new guidelines do not apply to people who received the Johnson & Johnson/Janssen vaccine or to people who take high-dose weekend-only steroids, as immunosuppression in this population remains unclear. If you are unsure if you/your child should receive a third vaccine dose, speak with your neuromuscular team directly for recommendations specific to your situation.
Vaccines Currently Available for COVID-19
|Pfizer||Moderna||Janssen Biotech/Johnson and Johnson|
|Vaccine Platform||mRNA encased in lipid nanoparticles (fat bubbles) to keep it from degrading||mRNA encased in lipid nanoparticles (fat bubbles) to keep it from degrading||Recombinant, replication-incompetent human adenovirus type 26 vector|
|Age of Inclusion||12 years +||18 years +||18 years +|
|Accessibility||Storage between -94 degrees Fahrenheit (institutional research freezers), stable x5 days after thaw||-4 degrees Fahrenheit (regular freezer), stable x30 days after thaw and at room temperature for 12 hours||36 degrees Fahrenheit to 46 degrees Fahrenheit (regular refrigerator); or 47 degrees Fahrenheit to 77 degrees Fahrenheit (room temperature) for up to 12 hours|
|Dosing Schedule||2 injections given 3 weeks apart||2 injections given 28 days apart||Single dose|
|Efficacy||95% effective||95% effective||85% effective in preventing severe/critical COVID-19 occurring at least 28 days after vaccination, 100% effective in preventing death|
|Possible Side Effects||Pain at injection site, fatigue, mild fever, headache, muscle pain, joint pain, fever; younger adults have reported more side effects than older adults||Pain at injection site, fatigue, mild fever, headache, muscle pain, joint pain, fever; younger adults have reported more side effects than older adults||Pain at the injection site, headache, fatigue, muscle aches and nausea|
|Need for future booster shots||Yes, if immunocompromised. Administer at least 28 days after second dose.||Yes, if immunocompromised. Administer at least 28 days after second dose.||Unknown|
* Table reflects COVID-19 vaccines that have received emergency use authorization from the US Food and Drug Administration (FDA) as of August 13, 2021.