Edasalonexent (CAT-1004)

Edasalonexent (CAT-1004)

Status

Phase |||

Therapeutic Approach

Reducing Inflammation

The muscles of individuals with Duchenne are constantly in a state of inflammation. Edasalonexent is an oral small molecule investigational drug candidate that inhibits NF-kB, a potent promoter of inflammation. By inhibiting NF-kB, it is thought that edasalonexent may reduce muscle damage and increase muscle regeneration in boys with Duchenne without the side effects of steroids.

Status

On October 26, 2020 Catabasis announced that the Phase 3 PolarisDMD trial of edasalonexent in Duchenne muscular dystrophy did not meet its primary or secondary endpoints. PPMD and Catabasis hosted a webinar on October 27th to discuss the trial and results in more detail, as well as the company’s plans for the edasalonexent program going forward. Families participating in the GalaxyDMD open-label extension trial are encouraged to reach out to their site directly.

Sponsor

This program is sponsored by Catabasis Pharmaceuticals.

Related Studies

ONGOING
PolarisDMD (Edasalonexent)
OPEN LABEL EXTENSION
Galaxy DMD (Open-Label Extension Study of Edasalonexent)

Media Library

OCTOBER 2020

Webinar: Catabasis Phase 3 PolarisDMD Trial Results

On October 26, 2020 Catabasis announced that the Phase 3 PolarisDMD trial of edasalonexent in Duchenne muscular dystrophy did not meet its primary or secondary endpoints. PPMD and Catabasis hosted a webinar on October 27th to discuss the trial and results in more detail, as well as the company’s plans for the edasalonexent program going forward. Families participating in the GalaxyDMD open-label extension trial are encouraged to reach out to their site directly.
JULY 2020

Catabasis Presents at the PPMD 2020 Virtual Annual Conference

Pre-recorded content for PPMD's 2020 Virtual Annual Conference On-Demand Library
JUNE 2019

Catabasis Presents at the PPMD 2019 Annual Conference

NOVEMBER 2018

Webinar: PolarisDMD – Phase 3 Clinical Trial of Edasalonexent

On November 7, 2018, Catabasis joined Parent Project Muscular Dystrophy for a webinar to discuss the Phase 3 PolarisDMD clinical trial studying edasalonexent in Duchenne muscular dystrophy, which is enrolling boys ages 4 to 7 (up to 8th birthday) regardless of mutation type who have not been on steroids for at least 6 months.
JUNE 2018

Catabasis Presents at the PPMD 2018 Annual Conference

OCT 2017

Webinar: MoveDMD Trial Open-Label Extension Results

PPMD and Catabasis Pharmaceuticals hosted a webinar on October 11, 2017 to hear a community update on the results from the open-label extension of the MoveDMD trial.
FEB 2017

Webinar: MoveDMD Trial: Catabasis Provides Update

The Catabasis team spoke to our community on February 2, 2017 to discuss what they learned from this latest trial and what comes next in the MoveDMD program.

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